Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus
Joint Authors
Ou, Yangping
Geng, Yi
Feng, Yang
Huang, Xiaoli
Duan, Yajiao
Fan, Wei
Wang, Kaiyu
Deng, Yongqiang
Chen, Defang
Yang, Shiyong
Duan, Jing
Du, Zongjun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
As an environmental and industrial pollutant, cadmium (Cd) can cause a broad spectrum of toxicological effects.
Multiple organs, especially the liver, are considerably affected by Cd in both humans and animals.
We investigated the protective effects of metallothionein (MT) and vitamin E (VE) supplementation on Cd-induced apoptosis in the grass carp (Ctenopharyngodon idellus) liver.
Grass carp were divided into four groups: the control group, Cd + phosphate-buffered saline (PBS) group, Cd + VE group, and Cd + MT group.
All fish were injected with CdCl2 on the first day and then VE, MT, and PBS were given 4 days postinjection, respectively.
The results showed that Cd administration resulted in liver poisoning in grass carp, which was expressed as an increase in Cd contents, malondialdehyde (MDA) concentration, percentage of hepatocyte apoptosis, and apoptosis-related gene mRNA transcript expression.
However, VE and MT treatments protected against Cd-induced hepatotoxicity in grass carp by decreasing Cd contents, lipid peroxidation, and histological damage and reducing the percentage of hepatocyte apoptosis by regulating related mRNA transcript expression.
These data demonstrate that oxidative stress and activation of the caspase signaling cascade play a critical role in Cd-induced hepatotoxicity.
However, VE and MT alleviate Cd-induced hepatotoxicity through their antioxidative and antiapoptotic effects, and MT has a more powerful effect than VE.
American Psychological Association (APA)
Duan, Yajiao& Duan, Jing& Feng, Yang& Huang, Xiaoli& Fan, Wei& Wang, Kaiyu…[et al.]. 2018. Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212388
Modern Language Association (MLA)
Duan, Yajiao…[et al.]. Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212388
American Medical Association (AMA)
Duan, Yajiao& Duan, Jing& Feng, Yang& Huang, Xiaoli& Fan, Wei& Wang, Kaiyu…[et al.]. Hepatoprotective Activity of Vitamin E and Metallothionein in Cadmium-Induced Liver Injury in Ctenopharyngodon idellus. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212388
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212388