Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes
Joint Authors
Furue, Masutaka
Mitoma, Chikage
Fuyuno, Yoko
Yasumatsu, Mao
Morino-Koga, Saori
Tanaka, Yuka
Uchi, Hiroshi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The skin covers the outer surface of the body, so the epidermal keratinocytes within it are susceptible to reactive oxygen species (ROS) generated by environmental pollutants such as benzo(a)pyrene (BaP), a potent activator of aryl hydrocarbon receptor (AHR).
Antioxidant activity is generally mediated by the nuclear factor-erythroid 2-related factor-2 (NRF2) and heme oxygenase-1 (HO1) axis in human keratinocytes.
Perillaldehyde is the main component of Perilla frutescens, which is a medicinal antioxidant herb traditionally consumed in East Asia.
However, the effect of perillaldehyde on the AHR/ROS and/or NRF2/HO1 pathways remains unknown.
In human keratinocytes, we found that perillaldehyde (1) inhibited BaP-induced AHR activation and ROS production, (2) inhibited BaP/AHR-mediated release of the CCL2 chemokine, and (3) activated the NRF2/HO1 antioxidant pathway.
Perillaldehyde is thus potentially useful for managing inflammatory skin diseases or disorders related to oxidative stress.
American Psychological Association (APA)
Fuyuno, Yoko& Uchi, Hiroshi& Yasumatsu, Mao& Morino-Koga, Saori& Tanaka, Yuka& Mitoma, Chikage…[et al.]. 2018. Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212389
Modern Language Association (MLA)
Fuyuno, Yoko…[et al.]. Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212389
American Medical Association (AMA)
Fuyuno, Yoko& Uchi, Hiroshi& Yasumatsu, Mao& Morino-Koga, Saori& Tanaka, Yuka& Mitoma, Chikage…[et al.]. Perillaldehyde Inhibits AHR Signaling and Activates NRF2 Antioxidant Pathway in Human Keratinocytes. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212389