Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease
Joint Authors
Federico, Alessandro
Dallio, Marcello
Masarone, Mario
Gravina, Antonietta Gerarda
Persico, Marcello
Loguercio, Carmelina
Rosato, Valerio
Aglitti, Andrea
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-11
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Liver steatosis without alcohol consumption, namely, nonalcoholic fatty liver disease (NAFLD), is a common hepatic condition that encompasses a wide spectrum of presentations, ranging from simple accumulation of triglycerides in the hepatocytes without any liver damage to inflammation, necrosis, ballooning, and fibrosis (namely, nonalcoholic steatohepatitis) up to severe liver disease and eventually cirrhosis and/or hepatocellular carcinoma.
The pathophysiology of fatty liver and its progression is influenced by multiple factors (environmental and genetics), in a “multiple parallel-hit model,” in which oxidative stress plays a very likely primary role as the starting point of the hepatic and extrahepatic damage.
The aim of this review is to give a comprehensive insight on the present researches and findings on the role of oxidative stress mechanisms in the pathogenesis and pathophysiology of NAFLD.
With this aim, we evaluated the available data in basic science and clinical studies in this field, reviewing the most recent works published on this topic.
American Psychological Association (APA)
Masarone, Mario& Rosato, Valerio& Dallio, Marcello& Gravina, Antonietta Gerarda& Aglitti, Andrea& Loguercio, Carmelina…[et al.]. 2018. Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212390
Modern Language Association (MLA)
Masarone, Mario…[et al.]. Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212390
American Medical Association (AMA)
Masarone, Mario& Rosato, Valerio& Dallio, Marcello& Gravina, Antonietta Gerarda& Aglitti, Andrea& Loguercio, Carmelina…[et al.]. Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212390
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212390