Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats
Joint Authors
Cordero-Pérez, Paula
Alarcón-Galván, Gabriela
Torres-Gonzalez, Liliana
Muñoz-Espinosa, Linda E.
Perales Quintana, Marlene Marisol
Cienfuegos-Pecina, Eduardo
Pérez-Rodríguez, Edelmiro
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Introduction.
Kidney ischemia-reperfusion (I/R) injury is the main cause of delayed graft function in solid organ transplantation.
Sonchus oleraceus is a plant with well-known antioxidant and anti-inflammatory activities; however, its effects on renal I/R are unknown.
Objective.
To evaluate whether S.
oleraceus extract (S.O.e.) has nephroprotective activity in an I/R model in Wistar rats.
Materials and Methods.
Animal groups (n=6): sham, I/R (45 min/15 h), S.O.e (300 mg/kg p.o.), and S.O.e + I/R (300 mg/kg, p.o.; 45 min/15 h).
Renal function, proinflammatory cytokines, alanine aminotransferase, markers of oxidative stress, and histology were evaluated.
Results.
None of the mediators evaluated differed significantly between the S.O.e and sham groups.
Levels of blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), and proinflammatory cytokines were higher, and superoxide dismutase (SOD) was lower in the I/R group than in the sham group.
Histology showed tubular epithelial necrosis in the medulla and cortex in the I/R group.
In the S.O.e + I/R group, S.O.e pretreatment attenuated the I/R-induced increases in BUN, creatinine, MDA, and proinflammatory cytokines induced, SOD was maintained, and histology showed discontinuous necrosis in the medulla but no necrosis in the cortex.
Conclusions.
S.O.e was neither hepatotoxic nor nephrotoxic.
S.O.e.
pretreatment showed a nephroprotective effect against I/R.
American Psychological Association (APA)
Torres-Gonzalez, Liliana& Cienfuegos-Pecina, Eduardo& Perales Quintana, Marlene Marisol& Alarcón-Galván, Gabriela& Muñoz-Espinosa, Linda E.& Pérez-Rodríguez, Edelmiro…[et al.]. 2018. Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212391
Modern Language Association (MLA)
Torres-Gonzalez, Liliana…[et al.]. Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212391
American Medical Association (AMA)
Torres-Gonzalez, Liliana& Cienfuegos-Pecina, Eduardo& Perales Quintana, Marlene Marisol& Alarcón-Galván, Gabriela& Muñoz-Espinosa, Linda E.& Pérez-Rodríguez, Edelmiro…[et al.]. Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212391