Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats
Joint Authors
Helmi, Nawal
Salem, Neveen
Assaf, Naglaa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Platelet-rich plasma (PRP) has grown as an attractive biologic instrument in regenerative medicine for its powerful healing properties.
It is considered as a source of growth factors that may induce tissue repairing and improve fibrosis.
This product has proven its efficacy in multiple studies, but its effect on cisplatin-induced nephrotoxicity has not yet been elucidated.
The present investigation was performed to estimate the protective impact of platelet-rich plasma against cisplatin- (CP-) evoked nephrotoxicity in male rats.
Nephrotoxicity was induced in male Wistar rats by right uninephrectomy followed by CP administration.
Uninephrectomized rats were assigned into four groups: (1) control group, (2) PRP group, (3) CP group, and (4) CP + PRP group.
PRP was administered by subcapsular renal injection.
Renal function, inflammatory cytokines, and growth factor level as well as histopathological investigation were carried out.
Treatment with PRP attenuated the severity of CP-induced nephrotoxicity as evidenced by suppressed creatinine, blood urea nitrogen (BUN), and N-acetyl glucosaminidase (NAG) levels.
Moreover, PRP depressed intercellular adhesion molecule-1 (ICAM-1), kidney injury molecule-1 (KIM-1), caspase-3, and transforming growth factor-beta 1 (TGF-β1) levels, while enhanced the epidermal growth factor (EGF) level.
These biochemical results were reinforced by the histopathological investigation, which revealed restoration of normal renal tissue architectures.
These findings highlight evidence for the possible protective effects of PRP in a rat model of CP-induced nephrotoxicity, suggesting a new avenue for using PRP to improve the therapeutic index of cisplatin.
American Psychological Association (APA)
Salem, Neveen& Helmi, Nawal& Assaf, Naglaa. 2018. Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212400
Modern Language Association (MLA)
Salem, Neveen…[et al.]. Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212400
American Medical Association (AMA)
Salem, Neveen& Helmi, Nawal& Assaf, Naglaa. Renoprotective Effect of Platelet-Rich Plasma on Cisplatin-Induced Nephrotoxicity in Rats. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212400
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212400