Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients
Joint Authors
Uchida, Shunya
Kazama, Junichiro James
Waki, Kaito
Murase, Takayo
Nakamura, Takashi
Terawaki, Hiroyuki
Hayashi, Tomoya
Iijima, Ryutaro
Tani, Yoshihiro
Yoshimura, Kazunobu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Xanthine oxidase (XO), an isoform of xanthine oxidoreductase (XOR), is thought to increase the cardiovascular burden among chronic kidney disease (CKD) patients via oxidative radical production.
Plasma XOR redox, which is characterized by the ratio of XO to total XOR, changes under different oxidative conditions associated with kidney dysfunction.
However, the relationship between plasma XOR redox and oxidative stress (OS) is unclear.
Thus, we aimed to clarify whether OS is related to XOR redox.
We used the redox state of human serum albumin (HSA) as a marker to investigate the status of OS in CKD patients.
HSA is composed of human mercaptoalbumin (HMA), which possesses not oxidized cysteine residues, reversibly oxidized human nonmercaptoalbumin-1 (HNA-1), and strongly oxidized human nonmercaptoalbumin-2 (HNA-2).
The subjects included 13 nondialysis patients (7 males and 6 females) with varying degrees of kidney function.
We found that ƒ(HMA) was negatively (R=−0.692, P=0.0071) and ƒ(HNA-1) was positively (R=0.703, P=0.0058) correlated with plasma XO/XOR.
ƒ(HNA-2) showed no correlation with XO/XOR (R=0.146, P=0.6412), indicating that plasma XOR redox is not related to the irreversible oxidation of HSA.
In conclusion, plasma XOR redox is closely related to HSA redox, particularly reversible oxidation of HSA.
American Psychological Association (APA)
Terawaki, Hiroyuki& Hayashi, Tomoya& Murase, Takayo& Iijima, Ryutaro& Waki, Kaito& Tani, Yoshihiro…[et al.]. 2018. Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212402
Modern Language Association (MLA)
Terawaki, Hiroyuki…[et al.]. Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212402
American Medical Association (AMA)
Terawaki, Hiroyuki& Hayashi, Tomoya& Murase, Takayo& Iijima, Ryutaro& Waki, Kaito& Tani, Yoshihiro…[et al.]. Relationship between Xanthine Oxidoreductase Redox and Oxidative Stress among Chronic Kidney Disease Patients. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212402