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UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response
Joint Authors
Zhong, Julia Li
Ji, Ping
Nisar, Muhammad Farrukh
Wang, Mei
Shi, Guangwei
Bian, Chunxiang
Guo, Yingying
Wu, Yan
Li, Wei
Huang, Xiao
Jiang, Xuemei
Bartsch, Jörg W.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-18
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Brusatol (BR) is a potent inhibitor of Nrf2, a transcription factor that is highly expressed in cancer tissues and confers chemoresistance.
UVA-generated reactive oxygen species (ROS) can damage both normal and cancer cells and may be of potential use in phototherapy.
In order to provide an alternative method to treat the aggressive melanoma, we sought to investigate whether low-dose UVA with BR is more effective in eliminating melanoma cells than the respective single treatments.
We found that BR combined with UVA led to inhibition of A375 melanoma cell proliferation by cell cycle arrest in the G1 phase and triggers cell apoptosis.
Furthermore, inhibition of Nrf2 expression attenuated colony formation and tumor development from A375 cells in heterotopic mouse models.
In addition, cotreatment of UVA and BR partially suppressed Nrf2 and its downstream target genes such as HO-1 along with the PI3K/AKT pathway.
We propose that cotreatment increased ROS-induced cell cycle arrest and cellular apoptosis and inhibits melanoma growth by regulating the AKT-Nrf2 pathway in A375 cells which offers a possible therapeutic intervention strategy for the treatment of human melanoma.
American Psychological Association (APA)
Wang, Mei& Shi, Guangwei& Bian, Chunxiang& Nisar, Muhammad Farrukh& Guo, Yingying& Wu, Yan…[et al.]. 2018. UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212405
Modern Language Association (MLA)
Wang, Mei…[et al.]. UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1212405
American Medical Association (AMA)
Wang, Mei& Shi, Guangwei& Bian, Chunxiang& Nisar, Muhammad Farrukh& Guo, Yingying& Wu, Yan…[et al.]. UVA Irradiation Enhances Brusatol-Mediated Inhibition of Melanoma Growth by Downregulation of the Nrf2-Mediated Antioxidant Response. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1212405
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212405