Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification
Joint Authors
Yang, San-Nan
Yang, Yu-Chen S. H.
Wu, Pei-Ling
Yang, Yung-Ning
Suen, Jau-Ling
Yang, Chun-Hwa
Su, Yu-Tsun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Bacterial meningitis during the perinatal period may cause long-term neurological deficits.
The study investigated whether bacterial lipopolysaccharide (LPS) derived from E.
coli.
led to neuronal apoptosis with an impaired performance of long-term cognitive function involving the activation of histone modification in the TNF-α gene promoter.
Further, we looked into the therapeutic efficacy of granulocyte colony-stimulating factor (G-CSF) in a neonatal brain suffering from perinatal bacterial meningitis.
We applied the following research techniques: neurobehavioral tasks, confocal laser microscopy, chromatin immunoprecipitation, and Western blotting.
At postnatal day 10, the animals were subjected to LPS and/or G-CSF.
The target brain tissues were then collected at P17.
Some animals (P45) were studied using neurobehavioral tasks.
The LPS-injected group revealed significantly increased expression of NF-κB phosphorylation and trimethylated H3K4 in the TNFA gene promoter locus.
Furthermore, the caspase-3, neuronal apoptosis expression, and an impaired performance in cognitive functions were also found in our study.
Such deleterious outcomes described above were markedly alleviated by G-CSF therapy.
This study suggests that selective therapeutic action sites of G-CSF through epigenetic regulation in the TNFA gene promoter locus may exert a potentially beneficial role for the neonatal brain suffering from perinatal bacterial-induced meningitis.
American Psychological Association (APA)
Yang, Yung-Ning& Su, Yu-Tsun& Wu, Pei-Ling& Yang, Chun-Hwa& Yang, Yu-Chen S. H.& Suen, Jau-Ling…[et al.]. 2018. Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212408
Modern Language Association (MLA)
Yang, Yung-Ning…[et al.]. Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212408
American Medical Association (AMA)
Yang, Yung-Ning& Su, Yu-Tsun& Wu, Pei-Ling& Yang, Chun-Hwa& Yang, Yu-Chen S. H.& Suen, Jau-Ling…[et al.]. Granulocyte Colony-Stimulating Factor Alleviates Bacterial-Induced Neuronal Apoptotic Damage in the Neonatal Rat Brain through Epigenetic Histone Modification. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212408
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212408