Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response
Joint Authors
Surh, Young-Joon
Kim, Sena
Joe, Yeonsoo
Chung, Hun Taeg
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The ability of the host immune response is largely mediated by the proinflammatory cytokine production.
Physiological and pathological conditions of endoplasmic reticulum (ER) trigger unfolded protein response and contribute to the development or pathology of inflammatory diseases.
Under ER stress, unfolded protein response (UPR) signaling pathways participate in upregulating inflammatory cytokine production via NF-kappaB, MAPK, and GSK-3β.
Moreover, it has been suggested that ER stress crosstalks with toll-like receptor (TLR) signaling pathway to promote the production of proinflammatory cytokines.
In addition, TLR stimulation can lead to UPR activation to promote inflammation.
In this review, we will cover how proinflammatory cytokine production by UPR signaling can be induced or amplified in the presence or absence of TLR activation.
American Psychological Association (APA)
Kim, Sena& Joe, Yeonsoo& Surh, Young-Joon& Chung, Hun Taeg. 2018. Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212410
Modern Language Association (MLA)
Kim, Sena…[et al.]. Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212410
American Medical Association (AMA)
Kim, Sena& Joe, Yeonsoo& Surh, Young-Joon& Chung, Hun Taeg. Differential Regulation of Toll-Like Receptor-Mediated Cytokine Production by Unfolded Protein Response. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212410