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Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties
Joint Authors
Ghedini, Paulo César
Costa, Elson Alves
Pontarolo, Roberto
Campos, Francinete Ramos
Gil, Eric de Souza
Thomaz, Douglas Vieira
da Silva Neri, Hiasmin Franciely
de Oliveira, Thiago Sardinha
Cerqueira, Letícia Bonancio
Garcia, Luane Ferreira
Gil, Henric Pietro Vicente
Santos, Fernanda C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-21
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Pequi (Caryocar brasiliense) is an endemic species from Brazilian Cerrado, and their fruits are widely used in regional cuisine.
In this work, a crude hydroalcoholic extract (CHE) of C.
brasiliense leaves and its resulting fractions in hexane (HF), chloroform (CF), ethyl acetate (EAF), and butanol (BF) were investigated for their antioxidant properties and anticholinesterase activities.
The antioxidant properties were evaluated by free radical scavenging and electroanalytical assays, which were further correlated with the total phenolic content and LC-MS results.
The acetylcholinesterase and butyrylcholinesterase inhibitory activities were examined using Ellman’s colorimetric method.
The LC-MS analysis of EAF revealed the presence of gallic acid and quercetin.
CHE and its fractions, EAF and BF, showed anticholinesterase and antioxidant activities, suggesting the association of both effects with the phenolic content.
In addition, behavioral tests performed with CHE (10, 100, and 300 mg/kg) showed that it prevented mice memory impairment which resulted from aluminium intake.
Moreover, CHE inhibited brain lipid peroxidation and acetyl and butyryl-cholinesterase activities and the extract’s neuroprotective effect was reflected at the microscopic level.
Therefore, the leaves of pequi are a potential source of phenolic antioxidants and can be potentially used in treatments of memory dysfunctions, such as those associated with neurodegenerative disorders.
American Psychological Association (APA)
de Oliveira, Thiago Sardinha& Thomaz, Douglas Vieira& da Silva Neri, Hiasmin Franciely& Cerqueira, Letícia Bonancio& Garcia, Luane Ferreira& Gil, Henric Pietro Vicente…[et al.]. 2018. Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. Oxidative Medicine and Cellular Longevity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212411
Modern Language Association (MLA)
de Oliveira, Thiago Sardinha…[et al.]. Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. Oxidative Medicine and Cellular Longevity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212411
American Medical Association (AMA)
de Oliveira, Thiago Sardinha& Thomaz, Douglas Vieira& da Silva Neri, Hiasmin Franciely& Cerqueira, Letícia Bonancio& Garcia, Luane Ferreira& Gil, Henric Pietro Vicente…[et al.]. Neuroprotective Effect of Caryocar brasiliense Camb. Leaves Is Associated with Anticholinesterase and Antioxidant Properties. Oxidative Medicine and Cellular Longevity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212411