Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease
Joint Authors
Luo, Wei-Feng
Liu, Tong
Xu, Guoxu
Huang, Jiang
Li, Yi
Xiao, Jianjiang
Zhang, Qin
Wu, Guanhui
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The retinal changes have been identified in morphology and function in Parkinson’s disease (PD).
However, the controversial results suggest that it is incredible that only using a single method for testing retinal change to evaluate Parkinson’s disease.
The aim of this study was to assess retinal changes and increase the diagnostic efficacy of Parkinson’s disease with a combination of multifocal electroretinogram (mf-ERG) and spectral domain optical coherence tomography (SD-OCT) examinations.
Method.
Fifty-three PD patients and forty-one healthy controls were enrolled.
Subjects were assessed for retinal function using mf-ERG and retinal structure using SD-OCT.
Results.
The PD patients had a significantly decreased amplitude density of P1 and a delayed implicit time of P1 in some regions.
The macular retinal thickness, macular volume, and average RNFL thickness were decreased in PD.
The AUC of a single parameter of either retinal function or structure was low.
Both of them were higher in diagnostic value to discriminate PD patients.
Conclusion.
The amplitude density of P1 combined with macular volume can get a high diagnostic efficacy to discriminate between participants with or without PD.
It indicates that a combination of mf-ERG and SD-OCT provides a good clinical biomarker for diagnosis of PD.
American Psychological Association (APA)
Huang, Jiang& Li, Yi& Xiao, Jianjiang& Zhang, Qin& Xu, Guoxu& Wu, Guanhui…[et al.]. 2018. Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212461
Modern Language Association (MLA)
Huang, Jiang…[et al.]. Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212461
American Medical Association (AMA)
Huang, Jiang& Li, Yi& Xiao, Jianjiang& Zhang, Qin& Xu, Guoxu& Wu, Guanhui…[et al.]. Combination of Multifocal Electroretinogram and Spectral-Domain OCT Can Increase Diagnostic Efficacy of Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212461