Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial
Joint Authors
Lawrence, Blake J.
Gasson, Natalie
Johnson, Andrew R.
Booth, Leon
Loftus, Andrea M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study examined whether standard cognitive training, tailored cognitive training, transcranial direct current stimulation (tDCS), standard cognitive training + tDCS, or tailored cognitive training + tDCS improved cognitive function and functional outcomes in participants with PD and mild cognitive impairment (PD-MCI).
Forty-two participants with PD-MCI were randomized to one of six groups: (1) standard cognitive training, (2) tailored cognitive training, (3) tDCS, (4) standard cognitive training + tDCS, (5) tailored cognitive training + tDCS, or (6) a control group.
Interventions lasted 4 weeks, with cognitive and functional outcomes measured at baseline, post-intervention, and follow-up.
The trial was registered with the Australian New Zealand Clinical Trials Registry (ANZCTR: 12614001039673).
While controlling for moderator variables, Generalized Linear Mixed Models (GLMMs) showed that when compared to the control group, the intervention groups demonstrated variable statistically significant improvements across executive function, attention/working memory, memory, language, activities of daily living (ADL), and quality of life (QOL; Hedge’s g range = 0.01 to 1.75).
More outcomes improved for the groups that received standard or tailored cognitive training combined with tDCS.
Participants with PD-MCI receiving cognitive training (standard or tailored) or tDCS demonstrated significant improvements on cognitive and functional outcomes, and combining these interventions provided greater therapeutic effects.
American Psychological Association (APA)
Lawrence, Blake J.& Gasson, Natalie& Johnson, Andrew R.& Booth, Leon& Loftus, Andrea M.. 2018. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212463
Modern Language Association (MLA)
Lawrence, Blake J.…[et al.]. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial. Parkinson’s Disease No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212463
American Medical Association (AMA)
Lawrence, Blake J.& Gasson, Natalie& Johnson, Andrew R.& Booth, Leon& Loftus, Andrea M.. Cognitive Training and Transcranial Direct Current Stimulation for Mild Cognitive Impairment in Parkinson’s Disease: A Randomized Controlled Trial. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212463
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212463