Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease
Joint Authors
Shu, Li
Xu, Qian
Yan, Xin-xiang
Tang, Bei-sha
Pan, Hongxu
Sun, Qiying
Liang, Dongxiao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-05
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Inflammation has been demonstrated to be involved in Parkinson’s disease (PD) pathogenesis.
There were evidences that the disturbance of the protective function of IL-10 gene contributed to PD.
In our study, haplotype analyses were conducted of IL-10 rs1800871 and rs1800872 on 371 PD patients.
Because the two SNPs exposed significant linkage disequilibrium demonstrated by Haploview software, we included 177 carriers of both rs1800871 and rs1800872 and 190 noncarriers in clinical phenotype analyses.
As to nonmotor symptoms, the score of the gastrointestinal dysfunction domain in Nonmotor Symptom Scale (NMSS) was lower in the carrier group of both SNPs than in the noncarrier group in PD patients (SC: −0.198, p:0.023).
Other nonmotor symptoms reflected by relevant rating scales showed negative results.
As to comorbidity, no significant statistical significance was observed between the two SNPs and Charlson Comorbidity Index (CCI).
In conclusion, we found less severe gastrointestinal dysfunctions of both IL-10 rs1800871 and rs1800872 carriers than noncarriers in PD.
American Psychological Association (APA)
Shu, Li& Liang, Dongxiao& Pan, Hongxu& Xu, Qian& Yan, Xin-xiang& Tang, Bei-sha…[et al.]. 2018. Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212475
Modern Language Association (MLA)
Shu, Li…[et al.]. Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212475
American Medical Association (AMA)
Shu, Li& Liang, Dongxiao& Pan, Hongxu& Xu, Qian& Yan, Xin-xiang& Tang, Bei-sha…[et al.]. Gastrointestinal Dysfunctions Are Associated with IL-10 Variants in Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212475
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212475