Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson’s Disease
Joint Authors
Gould, François D. H.
Gross, Andrew
German, Rebecca Z.
Richardson, Jason R.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-11
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Swallowing disorders in Parkinson’s disease are not responsive to dopamine depletion therapy and contribute to morbidity.
They are poorly understood owing to a lack of adequate models.
We present the first evidence of oropharyngeal changes in a rotenone toxicity model of Parkinson’s disease.
Rats were recorded while feeding before and after daily rotenone injections at two different doses (2.75 mg/kg and 3 mg/kg).
The higher dose had a much more severe parkinsonian phenotype than the low dose.
Timing and amplitude of chewing changed, as did the coordination of chewing and swallowing.
Dose-dependent effects were evident.
These preliminary results indicate that future research in toxicological models of Parkinson’s disease should incorporate the study of oropharyngeal dysfunction.
A better understanding of nongenetic models of Parkinson’s disease in feeding may open new avenues for research into the neurological and behavioral bases for swallowing dysfunction in Parkinson’s disease.
American Psychological Association (APA)
Gould, François D. H.& Gross, Andrew& German, Rebecca Z.& Richardson, Jason R.. 2018. Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212480
Modern Language Association (MLA)
Gould, François D. H.…[et al.]. Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212480
American Medical Association (AMA)
Gould, François D. H.& Gross, Andrew& German, Rebecca Z.& Richardson, Jason R.. Evidence of Oropharyngeal Dysfunction in Feeding in the Rat Rotenone Model of Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212480