Prevalence and Clinical Characteristics of Probable REM Behavior Disorder in Thai Parkinson’s Disease Patients
Joint Authors
Gomutbutra, Patama
Kanjanaratanakorn, Kittika
Tiyapun, Nantaporn
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Previous studies have shown that Parkinson’s disease (PD) patients who have REM behavior disorder (PD with RBD) might be a PD subtype since they have different symptom clusters and disease trajectories from PD without RBD.
Objective.
To study the prevalence of PD with pRBD and to compare the clinical characteristics with PD without pRBD.
The feasibility of clinical interview of items adopted from the Mayo Sleep Questionnaire was also to be determined.
Methods.
A total of 140 Parkinson's patients visiting neurological clinics during January to December 2016 were enrolled in this study.
“Probable RBD (pRBD)” was defined as present when the patient answered “yes” to a question adapted from the first Mayo Sleep Questionnaire (MSQ).
The demographic data, motor symptoms, and nonmotor symptoms were obtained.
Results.
The prevalence of pRBD among this study’s PD patients was 48.5% (68 out of the total of 140).
The median onset of RBD before PD diagnosis was 5 years (range: 0–11 years).
By comparison of PD with pRBD and PD without pRBD, this study showed significant difference in the levodopa equivalent dose (742 mg/day versus 566 mg/day; p<0.01), prevalence of symptomatic orthostatic hypotension (35.3% versus 8.3%; p<0.01).
The multivariable analysis found that pRBD is independently associated with orthostatic hypotension (OR = 5.02, p<0.01).
Conclusion.
The findings regarding prevalence and main clinical features of PD with pRBD in this study were similar to those of a previous study of PD with polysomnogram- (PSG-) proven RBD.
This study hypothesized that interviewing by adopted MSQ may be a cost-effective tool for screening RBD.
Further studies with direct comparison are needed.
American Psychological Association (APA)
Gomutbutra, Patama& Kanjanaratanakorn, Kittika& Tiyapun, Nantaporn. 2018. Prevalence and Clinical Characteristics of Probable REM Behavior Disorder in Thai Parkinson’s Disease Patients. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212484
Modern Language Association (MLA)
Gomutbutra, Patama…[et al.]. Prevalence and Clinical Characteristics of Probable REM Behavior Disorder in Thai Parkinson’s Disease Patients. Parkinson’s Disease No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212484
American Medical Association (AMA)
Gomutbutra, Patama& Kanjanaratanakorn, Kittika& Tiyapun, Nantaporn. Prevalence and Clinical Characteristics of Probable REM Behavior Disorder in Thai Parkinson’s Disease Patients. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212484
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212484