Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson’s Disease: A Pilot Study
Joint Authors
De Fabregues, Oriol
Ferré, Alex
Romero, Odile
Quintana, Manuel
Álvarez-Sabin, José
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Sleep problems in patients with advanced Parkinson’s disease (PD) have a deleterious impact on quality of life.
Objective.
To assess the effect of levodopa-carbidopa intestinal gel (LCIG) infusion on sleep quality in advanced PD patients.
Methods.
Seven patients participated in a prospective pilot study.
Before and after 6 months of LCIG infusion, an overnight polysomnography was performed and the Epworth Sleepiness Scale, fatigue scale, Pittsburgh Sleep Quality Index, Beck Depression Inventory, and the Hamilton Anxiety Rating Scale were administered.
Results.
PSG showed low sleep efficiency.
REM sleep without atony was found in 5 patients.
After 6 months of LCIG infusion, the percentage of REM sleep decreased as well as the number of arousals especially due to reduction of spontaneous arousals and periodic leg movements during REM sleep, but differences were not statistically significant.
Also, scores of all study questionnaires showed a tendency to improve.
Conclusion.
The results show a trend toward an improvement of sleep quality after 6 months of LCIG infusion, although differences as compared to pretreatment values were not statistically significant.
The sleep architecture was not modified by LCIG.
Further studies with larger study samples are needed to confirm these preliminary findings.
American Psychological Association (APA)
De Fabregues, Oriol& Ferré, Alex& Romero, Odile& Quintana, Manuel& Álvarez-Sabin, José. 2018. Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson’s Disease: A Pilot Study. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212491
Modern Language Association (MLA)
De Fabregues, Oriol…[et al.]. Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson’s Disease: A Pilot Study. Parkinson’s Disease No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212491
American Medical Association (AMA)
De Fabregues, Oriol& Ferré, Alex& Romero, Odile& Quintana, Manuel& Álvarez-Sabin, José. Sleep Quality and Levodopa Intestinal Gel Infusion in Parkinson’s Disease: A Pilot Study. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212491
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212491