The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease
Joint Authors
Weng, Minrui
Xie, Xiaoji
Liu, Chao
Lim, Kah-Leong
Zhang, Cheng-wu
Li, Lin
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by progressive loss of dopaminergic neurons in the substantia nigra.
The precise mechanism underlying pathogenesis of PD is not fully understood, but it has been widely accepted that excessive reactive oxygen species (ROS) are the key mediator of PD pathogenesis.
The causative factors of PD such as gene mutation, neuroinflammation, and iron accumulation all could induce ROS generation, and the later would mediate the dopaminergic neuron death by causing oxidation protein, lipids, and other macromolecules in the cells.
Obviously, it is of mechanistic and therapeutic significance to understand where ROS are derived and how ROS induce dopaminergic neuron damage.
In the present review, we try to summarize and discuss the main source of ROS in PD and the key pathways through which ROS mediate DA neuron death.
American Psychological Association (APA)
Weng, Minrui& Xie, Xiaoji& Liu, Chao& Lim, Kah-Leong& Zhang, Cheng-wu& Li, Lin. 2018. The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease. Parkinson’s Disease،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212492
Modern Language Association (MLA)
Weng, Minrui…[et al.]. The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease. Parkinson’s Disease No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212492
American Medical Association (AMA)
Weng, Minrui& Xie, Xiaoji& Liu, Chao& Lim, Kah-Leong& Zhang, Cheng-wu& Li, Lin. The Sources of Reactive Oxygen Species and Its Possible Role in the Pathogenesis of Parkinson’s Disease. Parkinson’s Disease. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212492