Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγRXR Heterodimerization
Joint Authors
Zheng, Baodong
Hu, Jiamiao
Zhou, Arong
Cheung, Peter C. K.
Zeng, Shaoxiao
Lin, Shaoling
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
GPR43, a G-protein coupled receptor recognizing short-chain fatty acids, has been reported to participate in many biological functions of white adipocytes, such as adipogenesis and lipolysis.
However, the functional role of GPR43 in brown adipocytes is still not clear.
In this study, we investigated the effects of the PPARγ agonist rosiglitazone on GPR43 expression in brown adipogenesis.
The results demonstrated that GPR43 was expressed during the late phase of brown adipocyte differentiation, which could be further augmented by adipogenic agent rosiglitazone treatment.
The PPARγ/RXR heterodimerization was found to be the key transcription factor for this enhancing effect of rosiglitazone on GPR43 expression.
Taken together, these results suggested GPR43 levels might be regulated by PPARγ-activated events during brown adipocytes differentiation and reflect the adipogenesis status of brown adipocytes.
American Psychological Association (APA)
Hu, Jiamiao& Zhou, Arong& Cheung, Peter C. K.& Zheng, Baodong& Zeng, Shaoxiao& Lin, Shaoling. 2018. Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγRXR Heterodimerization. PPAR Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212511
Modern Language Association (MLA)
Hu, Jiamiao…[et al.]. Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγRXR Heterodimerization. PPAR Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212511
American Medical Association (AMA)
Hu, Jiamiao& Zhou, Arong& Cheung, Peter C. K.& Zheng, Baodong& Zeng, Shaoxiao& Lin, Shaoling. Expression of GPR43 in Brown Adipogenesis Is Enhanced by Rosiglitazone and Controlled by PPARγRXR Heterodimerization. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212511