Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease
Joint Authors
Bloemer, Jenna
Pinky, Priyanka D.
Govindarajulu, Manoj
Amin, Rajesh H.
Suppiramaniam, Vishnu
Ghanei, Nila
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-21
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a chronic neurodegenerative disease characterized by abnormal protein accumulation, synaptic dysfunction, and cognitive impairment.
The continuous increase in the incidence of AD with the aged population and mortality rate indicates the urgent need for establishing novel molecular targets for therapeutic potential.
Peroxisome proliferator-activated receptor gamma (PPARγ) agonists such as rosiglitazone and pioglitazone reduce amyloid and tau pathologies, inhibit neuroinflammation, and improve memory impairments in several rodent models and in humans with mild-to-moderate AD.
However, these agonists display poor blood brain barrier permeability resulting in inadequate bioavailability in the brain and thus requiring high dosing with chronic time frames.
Furthermore, these dosing levels are associated with several adverse effects including increased incidence of weight gain, liver abnormalities, and heart failure.
Therefore, there is a need for identifying novel compounds which target PPARγ more selectively in the brain and could provide therapeutic benefits without a high incidence of adverse effects.
This review focuses on how PPARγ agonists influence various pathologies in AD with emphasis on development of novel selective PPARγ modulators.
American Psychological Association (APA)
Govindarajulu, Manoj& Pinky, Priyanka D.& Bloemer, Jenna& Ghanei, Nila& Suppiramaniam, Vishnu& Amin, Rajesh H.. 2018. Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease. PPAR Research،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1212512
Modern Language Association (MLA)
Govindarajulu, Manoj…[et al.]. Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease. PPAR Research No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1212512
American Medical Association (AMA)
Govindarajulu, Manoj& Pinky, Priyanka D.& Bloemer, Jenna& Ghanei, Nila& Suppiramaniam, Vishnu& Amin, Rajesh H.. Signaling Mechanisms of Selective PPARγ Modulators in Alzheimer’s Disease. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1212512
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212512