The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation
Joint Authors
Wang, Fan
Wang, Wenwen
Mo, Wenhui
Niu, Peiqin
Xia, Yujing
Chen, Kan
Weiqi, Dai
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Objective.
Previous studies have characterized the hepatoprotective and anti-inflammatory properties of oleanolic acid (OA).
This study aimed to investigate the molecular mechanisms of OA hepatoprotection in concanavalin A- (ConA-) induced acute liver injury.
Materials and Methods.
ConA (20 mg/kg) was intravenously injected to induce acute liver injury in Balb/C mice.
OA pretreatment (20, 40, and 80 mg/kg) was administered subcutaneously once daily for 3 consecutive days prior to treatment with ConA; 2, 8, and 24 h after ConA injection, the levels of serum liver enzymes and the histopathology of major factors and inflammatory cytokines were determined.
Results.
OA reduced the release of serum liver enzymes and inflammatory factors and prevented ConA mediated damage to the liver.
OA elevated the expression levels of peroxisome proliferator-activated receptor alpha (PPARα) and decreased the phosphorylation of c-Jun NH2-terminal kinase (JNK).
Conclusion.
OA exhibits anti-inflammatory properties during ConA-induced acute liver injury by attenuating apoptosis and autophagy through activation of PPARα and downregulation of JNK signaling.
American Psychological Association (APA)
Wang, Wenwen& Chen, Kan& Xia, Yujing& Mo, Wenhui& Wang, Fan& Weiqi, Dai…[et al.]. 2018. The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation. PPAR Research،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212513
Modern Language Association (MLA)
Wang, Wenwen…[et al.]. The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation. PPAR Research No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212513
American Medical Association (AMA)
Wang, Wenwen& Chen, Kan& Xia, Yujing& Mo, Wenhui& Wang, Fan& Weiqi, Dai…[et al.]. The Hepatoprotection by Oleanolic Acid Preconditioning: Focusing on PPARα Activation. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212513
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212513