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Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ
Joint Authors
Lu, Jie
Li, Jingjing
Li, Sainan
Liu, Tong
Kong, Rui
Xu, Shizan
Feng, Jiao
Wu, Liwei
Lu, Xiya
He, Weigang
Zheng, Yuejuan
Wang, Nan
Luo, Hui
Shi, Yanhong
Dai, Qi
Xia, Yujing
Zhou, Ying-Qun
Chen, Kan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Portulaca oleracea L.
is a traditional Chinese medicine, which has been used as adjuvant therapy for inflammatory bowel disease (IBD).
However, the mechanism of its activity in IBD still remains unclear.
Since previous studies have documented the anti-inflammatory effect of peroxisome proliferator activated receptors-γ (PPAR-γ), Portulaca regulation of PPAR-γ in inflammation was examined in current study.
Ulcerative colitis (UC) was generated by 5% dextran sulfate sodium (DSS) in mice and four groups were established as normal control, DSS alone, DSS plus mesalamine, and DSS plus Portulaca.
Severity of UC was evaluated by body weight, stool blood form, and length of colorectum.
Inflammation was examined by determination of inflammatory cytokines (TNF-a, IL-6, and IL-1a).
Portulaca extract was able to attenuate development of UC in DSS model similar to the treatment of mesalazine.
Moreover, Portulaca extract inhibited proinflammatory cytokines release and reduced the level of DSS-induced NF-κB phosphorylation.
Furthermore, Portulaca extract restored PPAR-γ level, which was reduced by DSS.
In addition, Portulaca extract protected DSS induced apoptosis in mice.
In conclusion, Portulaca extract can alleviate colitis in mice through regulation of inflammatory reaction, apoptosis, and PPAR-γ level; therefore, Portulaca extract can be a potential candidate for the treatment of IBD.
American Psychological Association (APA)
Kong, Rui& Luo, Hui& Wang, Nan& Li, Jingjing& Xu, Shizan& Chen, Kan…[et al.]. 2018. Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ. PPAR Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212521
Modern Language Association (MLA)
Kong, Rui…[et al.]. Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ. PPAR Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212521
American Medical Association (AMA)
Kong, Rui& Luo, Hui& Wang, Nan& Li, Jingjing& Xu, Shizan& Chen, Kan…[et al.]. Portulaca Extract Attenuates Development of Dextran Sulfate Sodium Induced Colitis in Mice through Activation of PPARγ. PPAR Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212521
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212521