Efficacy of Nalbuphine with Flurbiprofen on Multimodal Analgesia with Transverse Abdominis Plane Block in Elderly Patients Undergoing Open Gastrointestinal Surgery: A Randomized, Controlled, Double-Blinded Trial
Joint Authors
Mao, Yu
Chen, Lijian
Liu, Xuesheng
Zhang, Zhi
Cao, Yuanyuan
Mei, Bin
Gu, Erwei
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Objective.
To assess different doses of nalbuphine with flurbiprofen compared to sufentanil with flurbiprofen in multimodal analgesia efficacy for elderly patients undergoing gastrointestinal surgery with a transverse abdominis plane block (TAPB).
Methods.
158 elderly patients scheduling for elective open gastrointestinal surgery under general anesthesia and TAPB were randomly assigned to four groups according to different doses of nalbuphine with flurbiprofen in postoperative intravenous analgesia (PCIA).
Postoperative pain intensity, effective pressing numbers of PCIA, and adverse effects were recorded at 6, 12, 24, and 48 hours after surgery.
Results.
Postoperative pain intensity, effective pressing numbers, and the incidence of postoperative nausea and vomiting (PONV) were similar among the four groups after surgery, while the severity of PONV was decreased in Group L compared with Group S at 6, 12, and 48 h after surgery.
No individual experienced pruritus, respiratory depression, or hypotension.
Conclusions.
Low dose of nalbuphine (15 μg·kg−1·ml−1) combined with flurbiprofen is superior for elderly patients undergoing elective open gastrointestinal surgery with TAPB in terms of the efficient postoperative analgesia and decreased severity of PONV.
This trial is registered with NCT02984865.
American Psychological Association (APA)
Mao, Yu& Cao, Yuanyuan& Mei, Bin& Chen, Lijian& Liu, Xuesheng& Zhang, Zhi…[et al.]. 2018. Efficacy of Nalbuphine with Flurbiprofen on Multimodal Analgesia with Transverse Abdominis Plane Block in Elderly Patients Undergoing Open Gastrointestinal Surgery: A Randomized, Controlled, Double-Blinded Trial. Pain Research and Management،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212556
Modern Language Association (MLA)
Mao, Yu…[et al.]. Efficacy of Nalbuphine with Flurbiprofen on Multimodal Analgesia with Transverse Abdominis Plane Block in Elderly Patients Undergoing Open Gastrointestinal Surgery: A Randomized, Controlled, Double-Blinded Trial. Pain Research and Management No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1212556
American Medical Association (AMA)
Mao, Yu& Cao, Yuanyuan& Mei, Bin& Chen, Lijian& Liu, Xuesheng& Zhang, Zhi…[et al.]. Efficacy of Nalbuphine with Flurbiprofen on Multimodal Analgesia with Transverse Abdominis Plane Block in Elderly Patients Undergoing Open Gastrointestinal Surgery: A Randomized, Controlled, Double-Blinded Trial. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1212556
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212556