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Temporomandibular Disorders Related to Stress and HPA-Axis Regulation
Joint Authors
Rosén, Annika
Staniszewski, Kordian
Lygre, Henning
Berge, Trond
Bifulco, Ersilia
Kvinnsland, Siv
Willassen, Lisa
Helgeland, Espen
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Temporomandibular disorders (TMDs) are characterized by pain and dysfunction in the masticatory apparatus and the temporomandibular joint (TMJ).
Previous trauma, stress symptoms, psychosocial impairment, and catastrophizing have been related to TMD.
To assess if the hypothalamic-pituitary-adrenal (HPA) axis is upregulated in TMD patients, we performed a cross-sectional study with saliva from 44 TMD patients and 44 healthy sex- and age-matched controls for cortisol (F) and cortisone (E) with liquid chromatography-tandem mass spectrometry.
Furthermore, we calculated the F/E ratio for the evaluation of 11β-hydroxysteroid dehydrogenase activity.
We also assessed anxiety/depression and pain catastrophizing scores from a questionnaire that participants completed prior to the examination.
We found that F (P=0.01), E (P=0.04), the F/E ratio (P=0.002), and the sum of glucocorticoids (E + E) in saliva (P=0.02) were significantly higher in the TMD group.
Anxiety/depression and catastrophizing scores were also significantly higher in the TMD group (P<0.0001).
Our findings indicate that patients with TMDs may have an upregulated HPA axis with higher F secretion from the adrenal cortex.
Anxiety/depression and pain catastrophizing scores were significantly higher in the TMD group, and psychological factors may contribute to chronic upregulation of the HPA axis.
American Psychological Association (APA)
Staniszewski, Kordian& Lygre, Henning& Bifulco, Ersilia& Kvinnsland, Siv& Willassen, Lisa& Helgeland, Espen…[et al.]. 2018. Temporomandibular Disorders Related to Stress and HPA-Axis Regulation. Pain Research and Management،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212596
Modern Language Association (MLA)
Staniszewski, Kordian…[et al.]. Temporomandibular Disorders Related to Stress and HPA-Axis Regulation. Pain Research and Management No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1212596
American Medical Association (AMA)
Staniszewski, Kordian& Lygre, Henning& Bifulco, Ersilia& Kvinnsland, Siv& Willassen, Lisa& Helgeland, Espen…[et al.]. Temporomandibular Disorders Related to Stress and HPA-Axis Regulation. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1212596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212596