The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects
Joint Authors
Hu, Li
Wei, Hua
Zhou, Lili
Zhang, Huijuan
Chen, Jie
Lu, Xuejing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-19
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Nondeceptive placebo has demonstrated its efficiency in clinical practice.
Although the underlying mechanisms are still unclear, nondeceptive placebo effect and nondeceptive nocebo effect may be mediated by expectation.
To examine the extent to which expectation influences these effects, the present study compared nondeceptive placebo and nocebo effects with different expectation levels.
Seventy-two healthy female participants underwent a standard conditioning procedure to establish placebo and nocebo effects.
Sequentially, participants were randomized to one of the four experimental groups—baseline (BL), no expectation intervention (NoEI), expectation increasing (EI), and expectation decreasing (ED) groups, to receive either no intervention or interventions through different verbal suggestions that modulated their expectation.
Placebo and nocebo effects were established in all four groups after the conditioning phase.
However, after disclosing the placebo and nocebo, the analgesic and the hyperalgesic effects only persisted in the EI group, when compared with the BL group.
Our results provide evidence highlighting the critical role of increased expectation in nondeceptive placebo and nocebo effects.
The finding suggests that open-label placebo or nocebo per se might be insufficient to induce strong analgesic or hyperalgesic response and sheds insights into administrating open-label placebo and avoiding open-label nocebo in clinical practice.
American Psychological Association (APA)
Wei, Hua& Zhou, Lili& Zhang, Huijuan& Chen, Jie& Lu, Xuejing& Hu, Li. 2018. The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects. Pain Research and Management،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212615
Modern Language Association (MLA)
Wei, Hua…[et al.]. The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects. Pain Research and Management No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1212615
American Medical Association (AMA)
Wei, Hua& Zhou, Lili& Zhang, Huijuan& Chen, Jie& Lu, Xuejing& Hu, Li. The Influence of Expectation on Nondeceptive Placebo and Nocebo Effects. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1212615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212615