Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway
Joint Authors
Di Carlo, Marco
Salaffi, Fausto
Giacobazzi, Giovanni
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-07
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Chronic pain is nowadays considered not only the mainstay symptom of rheumatic diseases but also “a disease itself.” Pain is a multidimensional phenomenon, and in inflammatory arthritis, it derives from multiple mechanisms, involving both synovitis (release of a great number of cytokines) and peripheral and central pain-processing mechanisms (sensitization).
In the last years, the JAK-STAT pathway has been recognized as a pivotal component both in the inflammatory process and in pain amplification in the central nervous system.
This paper provides a summary on pain in inflammatory arthritis, from pathogenesis to clinimetric instruments and treatment, with a focus on the JAK-STAT pathway.
American Psychological Association (APA)
Salaffi, Fausto& Giacobazzi, Giovanni& Di Carlo, Marco. 2018. Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway. Pain Research and Management،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212617
Modern Language Association (MLA)
Salaffi, Fausto…[et al.]. Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway. Pain Research and Management No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212617
American Medical Association (AMA)
Salaffi, Fausto& Giacobazzi, Giovanni& Di Carlo, Marco. Chronic Pain in Inflammatory Arthritis: Mechanisms, Metrology, and Emerging Targets—A Focus on the JAK-STAT Pathway. Pain Research and Management. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212617