Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae)
Joint Authors
Silva, Juliana Rocha da
Souza, Aline Zanotelli de
Pirovani, Carlos Priminho
Costa, Helena
Silva, Aline
Dias, João Carlos Teixeira
Fontana, Renato
Delabie, Jacques Hubert Charles
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ectatomma tuberculatum has one of the most toxic venoms known among ants but there is no detailed study on its characteristics.
In light of this, knowing the venom’s chemical composition is of paramount importance in order to obtain information about the mechanisms of its components.
Several bioactive molecules have already been identified in Hymenoptera venoms, i.e., proteins such as phospholipases, hyaluronidases, and proteinases, as well as peptides.
Protein databases show that information on protein components of ant venoms has been recently growing exponentially.
In this study, we have identified proteins from the venom of Ectatomma tuberculatum by means of 2D PAGE, followed by tandem nanochromatography with mass spectrometry.
A total of 48 proteins were identified, of which 42 are involved in metabolic processes, transport, and structural support.
Moreover, six of them show similarity with not yet characterized proteins.
Nine proteins are related to the attack/defense or maintenance process of the colony (colony asepsis, conservation of venom constituents, venom diffusion on prey, paralysis of prey, alteration of homeostasis, and cellular toxicity).
Our findings may contribute to the identification of new natural prototypes of molecules to be synthesized and used in several areas of pharmacology.
American Psychological Association (APA)
Silva, Juliana Rocha da& Souza, Aline Zanotelli de& Pirovani, Carlos Priminho& Costa, Helena& Silva, Aline& Dias, João Carlos Teixeira…[et al.]. 2018. Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae). Psyche،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212657
Modern Language Association (MLA)
Silva, Juliana Rocha da…[et al.]. Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae). Psyche No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1212657
American Medical Association (AMA)
Silva, Juliana Rocha da& Souza, Aline Zanotelli de& Pirovani, Carlos Priminho& Costa, Helena& Silva, Aline& Dias, João Carlos Teixeira…[et al.]. Assessing the Proteomic Activity of the Venom of the Ant Ectatomma tuberculatum (Hymenoptera: Formicidae: Ectatomminae). Psyche. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1212657
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212657