Treatment Patterns and Survival among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France
Joint Authors
Kasper, Bernd
Kaye, James A.
Nagar, Saurabh P.
Mytelka, Daniel S.
D’yachkova, Yulia
Candrilli, Sean D.
Lorenzo, Maria
Lopez-Martin, Jose Antonio
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objective.
To describe real-world treatment patterns and outcomes for patients with advanced soft tissue sarcoma (STS) not amenable to surgery or radiotherapy in the United Kingdom, Spain, Germany, and France.
Methods.
Physicians completed a web-based medical record abstraction for adult patients with advanced STS (other than Kaposi’s sarcoma or gastrointestinal stromal tumor) who received ≥1 line of systemic therapy.
Clinical characteristics, treatments, tumor responses, and mortality data were recorded.
Results.
A total of 130 physicians provided data for 807 patients.
Patients’ mean age at advanced STS diagnosis was 57.1 (±12.3) years; 59% were male.
The most commonly identified histologic categories were leiomyosarcoma (28%), liposarcoma (13%), and rhabdomyosarcoma (11%).
Overall, 57% of patients received only 1 line of therapy, 32% received 2 lines of therapy, and 11% received ≥3 lines of therapy.
The most common first-line regimens were doxorubicin alone (41%), doxorubicin plus ifosfamide (19%), docetaxel plus gemcitabine (9%), paclitaxel alone (4%), and ifosfamide (4%).
Median overall survival from start of treatment was estimated to be 17.6 months (95% confidence interval, 15.6–19.0 months).
Conclusions.
In real-world clinical practice, advanced STS is most commonly treated with older therapies in the United Kingdom, Spain, Germany, and France.
New therapies that improve overall survival in advanced STS are needed.
American Psychological Association (APA)
Nagar, Saurabh P.& Mytelka, Daniel S.& Candrilli, Sean D.& D’yachkova, Yulia& Lorenzo, Maria& Kasper, Bernd…[et al.]. 2018. Treatment Patterns and Survival among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France. Complexity،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212824
Modern Language Association (MLA)
Nagar, Saurabh P.…[et al.]. Treatment Patterns and Survival among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France. Complexity No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1212824
American Medical Association (AMA)
Nagar, Saurabh P.& Mytelka, Daniel S.& Candrilli, Sean D.& D’yachkova, Yulia& Lorenzo, Maria& Kasper, Bernd…[et al.]. Treatment Patterns and Survival among Adult Patients with Advanced Soft Tissue Sarcoma: A Retrospective Medical Record Review in the United Kingdom, Spain, Germany, and France. Complexity. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1212824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212824