Cost-Effectiveness of Olaratumab in Combination with Doxorubicin for Patients with Soft Tissue Sarcoma in the United States
Joint Authors
Kaye, James A.
Hess, Lisa M.
D’yachkova, Yulia
Zuluaga-Sanchez, Santiago
Wolowacz, Sorrel E.
Hawe, Emma
Vickers, Adrian D.
Bertwistle, David
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Standard first-line treatments for advanced soft tissue sarcoma (STS) have changed little for 40 years, and outcomes have been poor.
Recently, the United States (US) Food and Drug Administration conditionally approved olaratumab in combination with doxorubicin (Olara + Dox) based on a randomized phase II trial that reported a significant 11.8-month improvement in median survival versus single-agent doxorubicin (Dox).
The present study investigated the cost-effectiveness of Olara + Dox compared with Dox and five other standard-of-care regimens from the US payer perspective.
Methods.
An economic model was constructed to estimate costs and outcomes over patients’ lifetimes from start of therapy.
Progression-free and overall survival were based on survival analysis of patient-level data and a meta-analysis.
Adverse-event rates were based on trials.
Costs were from published sources.
Results.
Olara + Dox resulted in an estimated additional 1.27 life-years (LYs) compared with Dox, with an increase in total expected lifetime costs of $133,653.
The incremental cost-effectiveness ratio (ICER) was estimated at $105,408 per LY gained; in a fully incremental analysis, all other regimens were dominated (higher costs and lower LYs or a higher ICER).
Conclusion.
Olara + Dox is cost-effective for STS treatment compared with Dox and other standard-of-care regimens at willingness-to-pay thresholds of $150,000 per LY and above.
American Psychological Association (APA)
Zuluaga-Sanchez, Santiago& Hess, Lisa M.& Wolowacz, Sorrel E.& D’yachkova, Yulia& Hawe, Emma& Vickers, Adrian D.…[et al.]. 2018. Cost-Effectiveness of Olaratumab in Combination with Doxorubicin for Patients with Soft Tissue Sarcoma in the United States. Complexity،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212829
Modern Language Association (MLA)
Zuluaga-Sanchez, Santiago…[et al.]. Cost-Effectiveness of Olaratumab in Combination with Doxorubicin for Patients with Soft Tissue Sarcoma in the United States. Complexity No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1212829
American Medical Association (AMA)
Zuluaga-Sanchez, Santiago& Hess, Lisa M.& Wolowacz, Sorrel E.& D’yachkova, Yulia& Hawe, Emma& Vickers, Adrian D.…[et al.]. Cost-Effectiveness of Olaratumab in Combination with Doxorubicin for Patients with Soft Tissue Sarcoma in the United States. Complexity. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1212829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212829