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Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation
Joint Authors
Magliocco, Anthony
Zhang, Qiang
Wang, Dian
Klimowicz, Alex
Harris, Jonathan
Simko, Jeff
DeLaney, Thomas
Kraybill, William
Kirsch, David G.
Kane, J. M.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Sarcoma mortality remains high despite adjuvant chemotherapy.
Biomarker predictors of treatment response and outcome could improve treatment selection.
Methods.
Tissue microarrays (TMAs) were created using pre- and posttreatment tumor from two prospective trials (MGH pilot and RTOG 9514) of neoadjuvant/adjuvant MAID chemotherapy and preoperative radiation.
Biomarkers were measured using automated computerized imaging (AQUA or ACIS).
Expression was correlated with disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS).
Results.
Specimens from 60 patients included 23 pretreatment (PRE), 40 posttreatment (POST), and 12 matched pairs (MPs).
In the MP set, CAIX, GLUT1, and PARP1 expression significantly decreased following neoadjuvant therapy, but p53 nuclear/cytoplasmic (N/C) ratio increased.
In the PRE set, no biomarker expression was associated with DFS, DDFS, or OS.
In the POST set, increased p53 N/C ratio was associated with a significantly decreased DFS and DDFS (HR 4.13, p=0.017; HR 4.16, p=0.016), while increased ERCC1 and XPF expression were associated with an improved DFS and DDFS.
No POST biomarkers were associated with OS.
Conclusions.
PRE biomarker expression did not predict survival outcomes.
Expression pattern changes after neoadjuvant chemoradiation supports the concepts of tumor reoxygenation, altered HIF-1α signaling, and a p53 nuclear accumulation DNA damage response.
Clinical Trial Registration.
NRG Oncology RTOG 9514 is registered with ClinicalTrials.gov.
The ClinicalTrials.gov Identifier is NCT00002791.
American Psychological Association (APA)
Kane, J. M.& Magliocco, Anthony& Zhang, Qiang& Wang, Dian& Klimowicz, Alex& Harris, Jonathan…[et al.]. 2018. Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation. Complexity،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212837
Modern Language Association (MLA)
Kane, J. M.…[et al.]. Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation. Complexity No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212837
American Medical Association (AMA)
Kane, J. M.& Magliocco, Anthony& Zhang, Qiang& Wang, Dian& Klimowicz, Alex& Harris, Jonathan…[et al.]. Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation. Complexity. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212837