![](/images/graphics-bg.png)
Treatment of Sarcoma Lung Metastases with Stereotactic Body Radiotherapy
Joint Authors
Gibbs, C. Parker
Zlotecki, Robert A.
Spiguel, Andre
Chan, Chung Ming
Lindsay, Adam D.
Haupt, Edward E.
Scarborough, Mark T.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
The most common site of sarcoma metastasis is the lung.
Surgical resection of pulmonary metastases and chemotherapy are treatment options that have been employed, but many patients are poor candidates for these treatments for multiple host or tumor-related reasons.
In this group of patients, radiation might provide a less morbid treatment alternative.
We sought to evaluate the efficacy of radiotherapy in the treatment of metastatic sarcoma to the lung.
Methods.
Stereotactic body radiotherapy (SBRT) was used to treat 117 pulmonary metastases in 44 patients.
Patients were followed with serial computed tomography imaging of the chest.
The primary endpoint was failure of control of a pulmonary lesion as measured by continued growth.
Radiation-associated complications were recorded.
Results.
The majority of patients (84%) received a total dose of 50 Gy per metastatic nodule utilizing an image-guided SBRT technique.
The median interval follow-up was 14.2 months (range 1.6–98.6 months).
Overall survival was 82% at two years and 50% at five years.
Of 117 metastatic nodules treated, six nodules showed failure of treatment (95% control rate).
Twenty patients (27%) developed new metastatic lesions and underwent further SBRT.
The side effects of SBRT included transient radiation pneumonitis n=6, cough n=2, rib fracture n=1, chronic pain n=1, dermatitis n=1, and dyspnea n=1.
Conclusion.
Stereotactic body radiotherapy is an effective and safe treatment for the ablation of pulmonary metastasis from sarcoma.
Further work is needed to evaluate the optimal role of SBRT relative to surgery or chemotherapy for treatment of metastatic sarcoma.
American Psychological Association (APA)
Lindsay, Adam D.& Haupt, Edward E.& Chan, Chung Ming& Spiguel, Andre& Scarborough, Mark T.& Zlotecki, Robert A.…[et al.]. 2018. Treatment of Sarcoma Lung Metastases with Stereotactic Body Radiotherapy. Complexity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212844
Modern Language Association (MLA)
Lindsay, Adam D.…[et al.]. Treatment of Sarcoma Lung Metastases with Stereotactic Body Radiotherapy. Complexity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1212844
American Medical Association (AMA)
Lindsay, Adam D.& Haupt, Edward E.& Chan, Chung Ming& Spiguel, Andre& Scarborough, Mark T.& Zlotecki, Robert A.…[et al.]. Treatment of Sarcoma Lung Metastases with Stereotactic Body Radiotherapy. Complexity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1212844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212844