Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action
Joint Authors
Kozlova, Elena
Chernysh, Aleksandr
Sergunova, Viktoria
Manchenko, Ekaterina
Moroz, Viktor
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-19
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Information Technology and Computer Science
Abstract EN
The ability of membranes of native human red blood cells (RBCs) to bend into the cell to a depth comparable in size with physiological deformations was evaluated.
For this, the methods of atomic force microscopy and atomic force spectroscopy were used.
Nonlinear patterns of deep deformation (up to 600 nm) of RBC membranes were studied in normal state and under the action of modifiers: fixator (glutaraldehyde), natural oxidant (hemin), and exogenous intoxicator (zinc ions), in vitro.
The experimental dependences of membrane bending for control RBC (normal) were approximated by the Hertz model to a depth up to 600 nm.
The glutaraldehyde fixator and modifiers increased the absolute value of Young’s modulus of membranes and changed the experimental dependences of probe indentation into the cells.
Up to some depth hHz, the force curves were approximated by the Hertz model, and for deeper indentations h>hHz, the degree of the polynomial function was changed, the membrane stiffness increased, and the pattern of indentation became another and did not obey the Hertz model.
Quantitative characteristics of nonlinear experimental dependences were calculated for deep bending of RBC membranes by approximating them by the degree polynomial function.
American Psychological Association (APA)
Kozlova, Elena& Chernysh, Aleksandr& Manchenko, Ekaterina& Sergunova, Viktoria& Moroz, Viktor. 2018. Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action. Scanning،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212868
Modern Language Association (MLA)
Kozlova, Elena…[et al.]. Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action. Scanning No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1212868
American Medical Association (AMA)
Kozlova, Elena& Chernysh, Aleksandr& Manchenko, Ekaterina& Sergunova, Viktoria& Moroz, Viktor. Nonlinear Biomechanical Characteristics of Deep Deformation of Native RBC Membranes in Normal State and under Modifier Action. Scanning. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1212868
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212868