AFM Characterization of the Internal Mammary Artery as a Novel Target for Arterial Stiffening
Joint Authors
Akhtar, Riaz
Chang, Zhuo
Paoletti, Paolo
Hansen, Maria Lyck
Beck, Hans Christian
Chen, Po-Yu
Rasmussen, Lars Melholt
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Information Technology and Computer Science
Abstract EN
Using the atomic force microscopy- (AFM-) PeakForce quantitative nanomechanical mapping (QNM) technique, we have previously shown that the adventitia of the human internal mammary artery (IMA), tested under dehydrated conditions, is altered in patients with a high degree of arterial stiffening.
In this study, we explored the nanoscale elastic modulus of the tunica media of the IMA in hydrated and dehydrated conditions from the patients with low and high arterial stiffening, as assessed in vivo by carotid-femoral pulse wave velocity (PWV).
In both hydrated and dehydrated conditions, the medial layer was significantly stiffer in the high PWV group.
The elastic modulus of the hydrated and dehydrated tunica media was significantly correlated with PWV.
In the hydrated condition, the expression activity of certain small leucine-rich repeat proteoglycans (SLRPs), which are associated with arterial stiffening, were found to be negatively correlated to the medial elastic modulus.
We also compared the data with our previous work on the IMA adventitia.
We found that the hydrated media and dehydrated adventitia are both suitable for reflecting the development of arterial stiffening and SLRP expression.
This comprehensive study of the nanomechanical properties integrated with the proteomic analysis in the IMAs demonstrates the possibility of linking structural properties and function in small biological samples with novel AFM methods.
The IMA is a suitable target for predicting arterial stiffening.
American Psychological Association (APA)
Chang, Zhuo& Paoletti, Paolo& Hansen, Maria Lyck& Beck, Hans Christian& Chen, Po-Yu& Rasmussen, Lars Melholt…[et al.]. 2018. AFM Characterization of the Internal Mammary Artery as a Novel Target for Arterial Stiffening. Scanning،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212976
Modern Language Association (MLA)
Chang, Zhuo…[et al.]. AFM Characterization of the Internal Mammary Artery as a Novel Target for Arterial Stiffening. Scanning No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1212976
American Medical Association (AMA)
Chang, Zhuo& Paoletti, Paolo& Hansen, Maria Lyck& Beck, Hans Christian& Chen, Po-Yu& Rasmussen, Lars Melholt…[et al.]. AFM Characterization of the Internal Mammary Artery as a Novel Target for Arterial Stiffening. Scanning. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1212976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1212976