Effect of Olanzapine on Clinical and Polysomnography Profiles in Patients with Schizophrenia
Joint Authors
Katshu, Mohammad Zia Ul Haq
Sarkar, Sukanto
Nizamie, S. Haque
Source
Schizophrenia Research and Treatment
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acute and short-term administration of olanzapine has a favorable effect on sleep in schizophrenia patients.
This study aimed to clarify the effect of olanzapine on polysomnographic profiles of schizophrenia patients during the acute phase of illness after controlling for previous drug exposure.
Twenty-five drug-naïve or drug-free schizophrenia patients were assessed at baseline and after six weeks of olanzapine treatment on Brief Psychiatric Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), and Udvalg for Kliniske Undersogelser (UKU) side-effect rating scale and a whole-night polysomnography; fifteen patients completed the study.
There was a significant reduction in all psychopathological variables with maximum reduction in PANSS total, BPRS total, and PANSS positive scores.
A significant increase in total sleep time (TST), sleep efficiency (SE), nonrapid eye movement (NREM) stage 1 duration, stage 3 duration, stage 4 duration, and stage 4 percentage of TST, number of rapid eye movement (REM) periods, REM duration, and REM percentage of TST was observed.
REM latency at baseline inversely predicted the reduction in BPRS total and PANSS total and positive scores.
In summary, short-term treatment with olanzapine produced significant improvement in clinical and polysomnography profiles of patients with schizophrenia with shorter REM latency predicting a good clinical response.
American Psychological Association (APA)
Katshu, Mohammad Zia Ul Haq& Sarkar, Sukanto& Nizamie, S. Haque. 2018. Effect of Olanzapine on Clinical and Polysomnography Profiles in Patients with Schizophrenia. Schizophrenia Research and Treatment،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1213042
Modern Language Association (MLA)
Katshu, Mohammad Zia Ul Haq…[et al.]. Effect of Olanzapine on Clinical and Polysomnography Profiles in Patients with Schizophrenia. Schizophrenia Research and Treatment No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1213042
American Medical Association (AMA)
Katshu, Mohammad Zia Ul Haq& Sarkar, Sukanto& Nizamie, S. Haque. Effect of Olanzapine on Clinical and Polysomnography Profiles in Patients with Schizophrenia. Schizophrenia Research and Treatment. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1213042
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213042