Long-Acting Injectable Second-Generation Antipsychotics Improve Negative Symptoms and Suicidal Ideation in Recent Diagnosed Schizophrenia Patients: A 1-Year Follow-up Pilot Study
Joint Authors
Pompili, Maurizio
Corigliano, Valentina
Comparelli, Anna
Mancinelli, Iginia
Montalbani, Benedetta
Lamis, Dorian A.
De Carolis, Antonella
Erbuto, Denise
Girardi, Paolo
Source
Schizophrenia Research and Treatment
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Long-acting injectable second-generation antipsychotics (LAI-SGA) are typically used to maintain treatment adherence in patients with chronic schizophrenia.
Recent research suggests that they may also provide an effective treatment strategy for patients with early-phase disease.
The aim of this study is to evaluate clinical and psychosocial outcomes among recent and long-term diagnosed schizophrenia outpatients treated with LAI-SGA during a follow-up period of 12 months.
Stable schizophrenia patients receiving LAI-SGA with 5 or less years of illness duration (n = 10) were compared to those with more than 5 years of illness duration (n = 15).
Clinical data was assessed through the Positive and Negative Syndrome Scale (PANSS), the Global Assessment of Functioning (GAF), the Columbia Suicide Severity Rating Scale (C-SSRS), the Recovery Style Questionnaire (RSQ), and the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT) Managing Emotion branch.
Recently diagnosed patients showed greater improvement versus patients diagnosed for more than 5 years in adjusted mean GAF score, in PANSS factor score for negative and depressive symptoms, and in severity and intensity of suicidal ideation.
Our preliminary findings support the hypothesis that LAI-SGA may influence the course of the illness if administered at the early phase of the illness.
However, replicate studies are needed, possibly with larger samples.
American Psychological Association (APA)
Corigliano, Valentina& Comparelli, Anna& Mancinelli, Iginia& Montalbani, Benedetta& Lamis, Dorian A.& De Carolis, Antonella…[et al.]. 2018. Long-Acting Injectable Second-Generation Antipsychotics Improve Negative Symptoms and Suicidal Ideation in Recent Diagnosed Schizophrenia Patients: A 1-Year Follow-up Pilot Study. Schizophrenia Research and Treatment،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213046
Modern Language Association (MLA)
Corigliano, Valentina…[et al.]. Long-Acting Injectable Second-Generation Antipsychotics Improve Negative Symptoms and Suicidal Ideation in Recent Diagnosed Schizophrenia Patients: A 1-Year Follow-up Pilot Study. Schizophrenia Research and Treatment No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213046
American Medical Association (AMA)
Corigliano, Valentina& Comparelli, Anna& Mancinelli, Iginia& Montalbani, Benedetta& Lamis, Dorian A.& De Carolis, Antonella…[et al.]. Long-Acting Injectable Second-Generation Antipsychotics Improve Negative Symptoms and Suicidal Ideation in Recent Diagnosed Schizophrenia Patients: A 1-Year Follow-up Pilot Study. Schizophrenia Research and Treatment. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213046