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Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation
Joint Authors
Vaiserman, Alexander
Sorochynska, Khrystyna
Sych, Nataliia
Duda, Alla
Kulebyakina, Kateryna
Krasnienkov, Dmytro
Vatlitsov, Denys
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Fetal stem cell- (FSC-) based therapy is a promising treatment option for many diseases.
The differentiation potential of FSCs is greater than that in adult stem cells, and they are more tissue-specific and have lower immunogenicity and better intrinsic homing than embryonic ones.
Embryonic stem cells have higher proliferative potential than FSCs but can cause teratomas.
Therefore, an evaluation of this potential represents an important biomedical challenge.
Since regulation of telomere length (TL) is one mechanism governing cellular proliferation, TL is a useful surrogate marker for cell replicative potential.
The prenatal dynamics of TL, however, has never been comprehensively studied.
In the present study, dynamics of TL and telomerase activity in the human fetal liver during 5–12 weeks of gestation is examined.
Both TL and telomerase activity were positively correlated with week of gestation.
For both parameters studied, the trend to increase was evident up to 10th week of gestation.
After that, they reached a plateau and remained stable.
These findings indicate that telomerase activity remains high during the fetal stage, suggesting high replicative capacity of FSCs and their considerable potential for transplantation therapies.
These findings, however, are preliminary only due to small sample size and require further evaluation.
American Psychological Association (APA)
Sorochynska, Khrystyna& Sych, Nataliia& Duda, Alla& Kulebyakina, Kateryna& Krasnienkov, Dmytro& Vaiserman, Alexander…[et al.]. 2018. Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213146
Modern Language Association (MLA)
Sorochynska, Khrystyna…[et al.]. Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213146
American Medical Association (AMA)
Sorochynska, Khrystyna& Sych, Nataliia& Duda, Alla& Kulebyakina, Kateryna& Krasnienkov, Dmytro& Vaiserman, Alexander…[et al.]. Dynamics of Telomere Length and Telomerase Activity in the Human Fetal Liver at 5–12 Weeks of Gestation. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213146