Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy
Joint Authors
Patsouris, Efstratios
Kletsas, Dimitris
Zografos, Georgios
Papanikolaou, Ioannis G.
Katselis, Charalambos
Apostolou, Konstantinos
Feretis, Themistoklis
Lymperi, Maria
Konstadoulakis, Manousos M.
Tsikalakis, Spiros
Saetta, Aggeliki A.
Agrogiannis, George
Papalois, Apostolos E.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
18
Abstract EN
Objective.
Adipose tissue stem cells (ADSCs) present a promising therapeutic method to alleviate liver failure (LF).
The purpose of this prospective study was to evaluate the efficacy of undifferentiated ADSC transplantation on liver regeneration and on the expression of liver regeneration- and liver-specific genes, following 60% partial hepatectomy (PHx).
Methods.
Sixty female rats were subjected to PHx and were transplanted with 106 or 2 × 106 ADSCs, either into the portal vein (PV) or into the hepatic parenchyma.
Animals of the control group were not transplanted and served as controls.
Animals were sacrificed on the 4th, the 7th, or the 15th postoperative day (POD).
Results.
The transplanted ADSCs were successfully engrafted into the liver parenchyma and ameliorated the histopathologic damage on the 7th and 15th POD.
All transplanted animals demonstrated a significantly higher liver regeneration rate on the 4th and 7th POD, compared with the control group.
The expression of hepatocyte growth factor, α-fetoprotein, tyrosine aminotransferase, hepatocyte nuclear factor 4a, and cytochrome P450 1A2 was significantly upregulated, compared with the control group.
Conclusions.
Although undifferentiated, ADSC transplantation significantly enhanced the liver regeneration process.
These findings may be proven clinically valuable, especially in cases of acute LF.
American Psychological Association (APA)
Apostolou, Konstantinos& Papanikolaou, Ioannis G.& Katselis, Charalambos& Feretis, Themistoklis& Kletsas, Dimitris& Konstadoulakis, Manousos M.…[et al.]. 2018. Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy. Stem Cells International،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1213147
Modern Language Association (MLA)
Apostolou, Konstantinos…[et al.]. Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy. Stem Cells International No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1213147
American Medical Association (AMA)
Apostolou, Konstantinos& Papanikolaou, Ioannis G.& Katselis, Charalambos& Feretis, Themistoklis& Kletsas, Dimitris& Konstadoulakis, Manousos M.…[et al.]. Undifferentiated Adipose Tissue Stem Cell Transplantation Promotes Hepatic Regeneration, Ameliorates Histopathologic Damage of the Liver, and Upregulates the Expression of Liver Regeneration- and Liver-Specific Genes in a Rat Model of Partial Hepatectomy. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1213147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213147