The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis
Joint Authors
Zhong, Jiang F.
Wu, Jiang
Zhang, Weiwei
Ran, Qian
Xiang, Yang
Li, Shengwen Calvin
Li, Zhongjun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-03
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
However, how BMSC differentiation affects hematopoiesis is poorly understood.
In this review, we focus on the role of BMSC differentiation in hematopoiesis.
We discussed the role of BMSCs and their progeny in hematopoiesis.
We also examine the mechanisms that cause differentiation bias of BMSCs in stress conditions including aging, irradiation, and chemotherapy.
Moreover, the differentiation balance of BMSCs is crucial to hematopoiesis.
We highlight the negative effects of differentiation bias of BMSCs on hematopoietic recovery after bone marrow transplantation.
Keeping the differentiation balance of BMSCs is critical for hematopoietic recovery.
This review summarises current understanding about how BMSC differentiation affects hematopoiesis and its potential application in improving hematopoietic recovery after bone marrow transplantation.
American Psychological Association (APA)
Wu, Jiang& Zhang, Weiwei& Ran, Qian& Xiang, Yang& Zhong, Jiang F.& Li, Shengwen Calvin…[et al.]. 2018. The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. Stem Cells International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213161
Modern Language Association (MLA)
Wu, Jiang…[et al.]. The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. Stem Cells International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1213161
American Medical Association (AMA)
Wu, Jiang& Zhang, Weiwei& Ran, Qian& Xiang, Yang& Zhong, Jiang F.& Li, Shengwen Calvin…[et al.]. The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213161