![](/images/graphics-bg.png)
Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation
Joint Authors
Worley, Kathryn E.
Chin, Amanda S.
Wan, Leo Q.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-02
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Left-right symmetry breaking is a complex developmental process and an important part of embryonic axis development.
As of yet, the biophysical mechanism behind LR asymmetry establishment remains elusive for the overall asymmetry of embryos as well as for the organ-specific asymmetry.
Here, we demonstrate that inherent cellular chirality is observable in the cells of early embryonic stages using a 3D Matrigel bilayer system.
Differentiation of human embryonic stem cells to three lineages corresponding to heart, intestine, and neural tissues demonstrates phenotype-specific inherent chiral biases, complementing the current knowledge regarding organ development.
The existence of inherent cellular chirality early in development and its correlation with organ asymmetry implicate cell chirality as a possible regulator in LR symmetry breaking.
American Psychological Association (APA)
Worley, Kathryn E.& Chin, Amanda S.& Wan, Leo Q.. 2018. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213188
Modern Language Association (MLA)
Worley, Kathryn E.…[et al.]. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213188
American Medical Association (AMA)
Worley, Kathryn E.& Chin, Amanda S.& Wan, Leo Q.. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells during Differentiation. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213188
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213188