Vulgaris activity against of Leishmania tropica promastigotes ; in vitro

Abstract EN

Cutaneous leishmaniasis (CL) is a major public health problem and an endemic disease in Iraqi population, Leishmania tropica is one of the causes of leishmaniasis in Baghdad.

Considering the inefficiency of current drugs and the fact that some varieties of Leishmania are resistant to these treatments, new drugs are being researched in order to find a more selective and effective therapy with fewer side effects.

Therefore, our research group conducted studies on new therapeutic agents.

This study is intended to investigate the effect ethanol extract of Chara vulgaris at concentrations (15.6-500) µg/mL in the growth rate and viability of leishmania tropica isolates and compared with pentostam (3.12-100) µg/mL In-vitro.

(15.6, 31.25, 62.5, 125, 250, 500 µg/mL) in vitro by MTT assay [3-(4.5-dimethylthiazol-2-yl)- 2.5-diphenyl tetrazolium bromide)], to investigate its effect on the proliferation of promastigotes.

Three incubation periods (24, 48, 72 hr.).