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Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations
Joint Authors
Durandt, Chrisna
Mellet, Juanita
Pepper, Michael S.
Wolmarans, Elize
Nel, Sulette
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-06
Country of Publication
Egypt
No. of Pages
7
Abstract EN
There is still much to learn about the cells used for cell- and gene-based therapies in the clinical setting.
Stem cells are found in virtually all tissues in the human body.
As a result, cells isolated from these tissues are a heterogeneous population consisting of various subpopulations including stem cells.
Several strategies have been used to isolate and define the subpopulations that constitute these heterogeneous populations, one of which is the side population (SP) assay.
SP cells are identified by their ability to efflux a fluorescent dye at a rate that is greater than the main cell population.
This elevated rate of dye efflux has been attributed to the expression of members of the ATP-binding cassette (ABC) transporter protein family.
SP cells have been identified in various tissues.
In this review, we discuss the research to date on SP cells, focussing on SP cells identified in haematopoietic stem cells, adipose-derived stromal cells, and dental pulp.
American Psychological Association (APA)
Wolmarans, Elize& Nel, Sulette& Durandt, Chrisna& Mellet, Juanita& Pepper, Michael S.. 2018. Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213295
Modern Language Association (MLA)
Wolmarans, Elize…[et al.]. Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213295
American Medical Association (AMA)
Wolmarans, Elize& Nel, Sulette& Durandt, Chrisna& Mellet, Juanita& Pepper, Michael S.. Side Population: Its Use in the Study of Cellular Heterogeneity and as a Potential Enrichment Tool for Rare Cell Populations. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213295