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Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production
Joint Authors
Luo, Fanyan
Wu, Wan-Zhou
Luo, Ying
Yan, Quan-Neng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia.
EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia.
However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown.
Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia.
No significant differences were found between postmenopausal females and age-matched males.
NO production showed positive correlation with the activity and count of circulating EPCs in patients with hypercholesterolemia.
Flow-mediated dilatation (FMD) is directly interrelated with EPC counts and function.
Our findings reveal that decreased EPC count and endothelial dysfunction lead to less NO production in hypercholesterolemic postmenopausal females.
Maintaining the EPC numbers and activity might be emerging as a potential therapeutic strategy to reduce the risk of cardiovascular injury in elder women.
American Psychological Association (APA)
Luo, Ying& Yan, Quan-Neng& Wu, Wan-Zhou& Luo, Fanyan. 2018. Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213298
Modern Language Association (MLA)
Luo, Ying…[et al.]. Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213298
American Medical Association (AMA)
Luo, Ying& Yan, Quan-Neng& Wu, Wan-Zhou& Luo, Fanyan. Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213298
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213298