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Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway
Joint Authors
Ren, Hui
Jiao, Feng
Tang, Wang
Huang, He
Zhang, Zhaofei
Liu, Donghua
Zhang, Hongyi
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-18
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Bone marrow-derived mesenchymal stem cells (BMSCs) are widely used in tissue engineering for regenerative medicine due to their multipotent differentiation potential.
However, their poor migration ability limits repair effects.
Icariin (ICA), a major component of the Chinese medical herb Herba Epimedii, has been reported to accelerate the proliferation, osteogenic, and chondrogenic differentiation of BMSCs.
However, it remains unknown whether ICA can enhance BMSC migration, and the possible underlying mechanisms need to be elucidated.
In this study, we found that ICA significantly increased the migration capacity of BMSCs, with an optimal concentration of 1 μmol/L.
Moreover, we found that ICA stimulated actin stress fiber formation in BMSCs.
Our work revealed that activation of the MAPK signaling pathway was required for ICA-induced migration and actin stress fiber formation.
In vivo, ICA promoted the recruitment of BMSCs to the cartilage defect region.
Taken together, these results show that ICA promotes BMSC migration in vivo and in vitro by inducing actin stress fiber formation via the MAPK signaling pathway.
Thus, combined administration of ICA with BMSCs has great potential in cartilage defect therapy.
American Psychological Association (APA)
Jiao, Feng& Tang, Wang& Huang, He& Zhang, Zhaofei& Liu, Donghua& Zhang, Hongyi…[et al.]. 2018. Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213300
Modern Language Association (MLA)
Jiao, Feng…[et al.]. Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213300
American Medical Association (AMA)
Jiao, Feng& Tang, Wang& Huang, He& Zhang, Zhaofei& Liu, Donghua& Zhang, Hongyi…[et al.]. Icariin Promotes the Migration of BMSCs In Vitro and In Vivo via the MAPK Signaling Pathway. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213300