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Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits
Joint Authors
Kang, Byung-jae
Choi, Seongjae
Kim, Jun-Hyung
Ha, Jeongho
Jeong, Bo-Ing
Jung, Yun Chan
Lee, Geun-Shik
Woo, Heung-Myong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-26
Country of Publication
Egypt
No. of Pages
10
Abstract EN
We investigated the effects of intra-articular injections of alginate-microencapsulated adipose tissue-derived mesenchymal stem cells (ASCs) during osteoarthritis (OA) development in a rabbit model of anterior cruciate ligament transection (ACLT).
We induced OA in mature New Zealand white rabbits by bilateral ACLT.
Stifle joints were categorised into four groups according to intra-articular injection materials.
Alginate microbeads and microencapsulated ASCs were prepared using the vibrational nozzle technology.
Two weeks after ACLT, the rabbits received three consecutive weekly intra-articular injections of 0.9% NaCl, alginate microbeads, ASCs, or microencapsulated ASCs, into each joint.
Nine weeks after ACLT, we euthanised the rabbits and collected bilateral femoral condyles for macroscopic, histological, and immunohistochemical analyses.
Macroscopic evaluation using the modified OA Research Society International (OARSI) score and total cartilage damage score showed that cartilage degradation on the femoral condyle was relatively low in the microencapsulated-ASC group.
Histological analysis of the lateral femoral condyles indicated that microencapsulated ASCs had significant chondroprotective effects.
Immunohistochemically, the expression of MMP-13 after the articular cartilage damage was relatively low in the microencapsulated-ASC-treated stifle joints.
During the development of experimental OA, as compared to ASCs alone, intra-articular injection of microencapsulated ASCs significantly decreased the progression and extent of OA.
American Psychological Association (APA)
Choi, Seongjae& Kim, Jun-Hyung& Ha, Jeongho& Jeong, Bo-Ing& Jung, Yun Chan& Lee, Geun-Shik…[et al.]. 2018. Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213306
Modern Language Association (MLA)
Choi, Seongjae…[et al.]. Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213306
American Medical Association (AMA)
Choi, Seongjae& Kim, Jun-Hyung& Ha, Jeongho& Jeong, Bo-Ing& Jung, Yun Chan& Lee, Geun-Shik…[et al.]. Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213306