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The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials
Joint Authors
Ambrosio, Javier R.
Ambriz, X.
de Lanerolle, P.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
11
Abstract EN
An understanding of the cytoskeleton’s importance in stem cells is essential for their manipulation and further clinical application.
The cytoskeleton is crucial in stem cell biology and depends on physical and chemicals signals to define its structure.
Additionally, cell culture conditions will be important in the proper maintenance of stemness, lineage commitment, and differentiation.
This review focuses on the following areas: the role of the actin cytoskeleton of stem cells during differentiation, the significance of cellular morphology, signaling pathways involved in cytoskeletal rearrangement in stem cells, and the mechanobiology and mechanotransduction processes implicated in the interactions of stem cells with different surfaces of biomaterials, such as nanotopography, which is a physical cue influencing the differentiation of stem cells.
Also, cancer stem cells are included since it is necessary to understand the role of their mechanical properties to develop new strategies to treat cancer.
In this context, to study the stem cells requires integrated disciplines, including molecular and cellular biology, chemistry, physics, and immunology, as well as mechanobiology.
Finally, since one of the purposes of studying stem cells is for their application in regenerative medicine, the deepest understanding is necessary in order to establish safety protocols and effective cell-based therapies.
American Psychological Association (APA)
Ambriz, X.& de Lanerolle, P.& Ambrosio, Javier R.. 2018. The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213310
Modern Language Association (MLA)
Ambriz, X.…[et al.]. The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213310
American Medical Association (AMA)
Ambriz, X.& de Lanerolle, P.& Ambrosio, Javier R.. The Mechanobiology of the Actin Cytoskeleton in Stem Cells during Differentiation and Interaction with Biomaterials. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213310
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213310