In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review
Joint Authors
Docheva, Denitsa
Janjic, Mila
Trickovic Janjic, Olivera
Wichelhaus, Andrea
Baumert, Uwe
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
17
Abstract EN
Cells from the mesenchymal lineage in the dental area, including but not limited to PDL fibroblasts, osteoblasts, and dental stem cells, are exposed to mechanical stress in physiological (e.g., chewing) and nonphysiological/therapeutic (e.g., orthodontic tooth movement) situations.
Close and complex interaction of these different cell types results in the physiological and nonphysiological adaptation of these tissues to mechanical stress.
Currently, different in vitro loading models are used to investigate the effect of different types of mechanical loading on the stress adaptation of these cell types.
We performed a systematic review according to the PRISMA guidelines to identify all studies in the field of dentistry with focus on mechanobiology using in vitro loading models applying uniaxial static compressive force.
Only studies reporting on cells from the mesenchymal lineage were considered for inclusion.
The results are summarized regarding gene expression in relation to force duration and magnitude, and the most significant signaling pathways they take part in are identified using protein-protein interaction networks.
American Psychological Association (APA)
Janjic, Mila& Docheva, Denitsa& Trickovic Janjic, Olivera& Wichelhaus, Andrea& Baumert, Uwe. 2018. In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review. Stem Cells International،Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1213319
Modern Language Association (MLA)
Janjic, Mila…[et al.]. In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review. Stem Cells International No. 2018 (2018), pp.1-17.
https://search.emarefa.net/detail/BIM-1213319
American Medical Association (AMA)
Janjic, Mila& Docheva, Denitsa& Trickovic Janjic, Olivera& Wichelhaus, Andrea& Baumert, Uwe. In Vitro Weight-Loaded Cell Models for Understanding Mechanodependent Molecular Pathways Involved in Orthodontic Tooth Movement: A Systematic Review. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-17.
https://search.emarefa.net/detail/BIM-1213319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213319