Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization
Joint Authors
Mizukami, Amanda
Swiech, Kamilla
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense research by academia and industry due to their unique features.
MSC can be easily isolated and expanded through in vitro culture by taking full advantage of their self-renewing capacity.
In addition, MSC exert immunomodulatory effects and can be differentiated into various lineages, which makes them highly attractive for clinical applications in cell-based therapies.
In this review, we attempt to provide a brief historical overview of MSC discovery, characterization, and the first clinical studies conducted.
The current MSC manufacturing platforms are reviewed with special attention regarding the use of bioreactors for the production of GMP-compliant clinically relevant cell numbers.
The first commercial MSC-based products are also addressed, as well as the remaining challenges to the widespread use of MSC-derived products.
American Psychological Association (APA)
Mizukami, Amanda& Swiech, Kamilla. 2018. Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization. Stem Cells International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213372
Modern Language Association (MLA)
Mizukami, Amanda& Swiech, Kamilla. Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization. Stem Cells International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1213372
American Medical Association (AMA)
Mizukami, Amanda& Swiech, Kamilla. Mesenchymal Stromal Cells: From Discovery to Manufacturing and Commercialization. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213372