Genome Editing Redefines Precision Medicine in the Cardiovascular Field
Joint Authors
Lahm, H.
Deutsch, Marcus-André
Dzilic, Elda
Dreßen, Martina
Wu, Sean M.
Krane, Markus
Doppler, Stefanie A.
Lange, R.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-14
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Genome editing is a powerful tool to study the function of specific genes and proteins important for development or disease.
Recent technologies, especially CRISPR/Cas9 which is characterized by convenient handling and high precision, revolutionized the field of genome editing.
Such tools have enormous potential for basic science as well as for regenerative medicine.
Nevertheless, there are still several hurdles that have to be overcome, but patient-tailored therapies, termed precision medicine, seem to be within reach.
In this review, we focus on the achievements and limitations of genome editing in the cardiovascular field.
We explore different areas of cardiac research and highlight the most important developments: (1) the potential of genome editing in human pluripotent stem cells in basic research for disease modelling, drug screening, or reprogramming approaches and (2) the potential and remaining challenges of genome editing for regenerative therapies.
Finally, we discuss social and ethical implications of these new technologies.
American Psychological Association (APA)
Dzilic, Elda& Lahm, H.& Dreßen, Martina& Deutsch, Marcus-André& Lange, R.& Wu, Sean M.…[et al.]. 2018. Genome Editing Redefines Precision Medicine in the Cardiovascular Field. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213376
Modern Language Association (MLA)
Dzilic, Elda…[et al.]. Genome Editing Redefines Precision Medicine in the Cardiovascular Field. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213376
American Medical Association (AMA)
Dzilic, Elda& Lahm, H.& Dreßen, Martina& Deutsch, Marcus-André& Lange, R.& Wu, Sean M.…[et al.]. Genome Editing Redefines Precision Medicine in the Cardiovascular Field. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213376
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213376