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Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Faslpr Mice
Joint Authors
Lee, Hong Kyung
Kim, Hyung Sook
Lee, Tae Yong
Kim, Kyung Suk
Kim, Youngsoo
Kim, Ki Hun
Kim, Ji Sung
Lee, Jae Hee
Ji, Ayoung
Chang, In Young
Han, Sang Bae
Hong, Jin Tae
Bae, Sang-Cheol
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-03
Country of Publication
Egypt
No. of Pages
10
Abstract EN
The combination of immunosuppressants and mesenchymal stem cells (MSCs) is a promising therapeutic strategy for systemic lupus erythematosus, since this approach reduces doses of immunosuppressants while maintaining the same therapeutic outcome.
However, it is unavoidable for MSCs to be exposed to immunosuppressants.
Here, we examined the combination effect of prednisone (PD) or mycophenolate mofetil (MMF) and MSCs.
We showed that PD or MMF in combination with MSCs showed better therapeutic effect than single therapy in lupus-prone MRL.Faslpr mice, as assessed by using the following readouts: prolongation of survival, decrease in anti-dsDNA and total IgG levels in serum, decrease in cytokine gene expression in spleen cells, and decrease in inflammatory cell infiltration into the kidney.
In vitro, immunosuppressants and MSCs inhibited T cell proliferation in a synergistic manner.
However, immunosuppressants did not affect MSC viability and functions such as TGF-β1 and PGE2 production, migration, and immunosuppressive capacity.
In summary, our study demonstrates that a combination of immunosuppressants and MSCs is a good strategy to reduce the side effects of PD and MMF without the loss of therapeutic outcome.
American Psychological Association (APA)
Lee, Hong Kyung& Kim, Ki Hun& Kim, Hyung Sook& Kim, Ji Sung& Lee, Jae Hee& Ji, Ayoung…[et al.]. 2018. Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Faslpr Mice. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213393
Modern Language Association (MLA)
Lee, Hong Kyung…[et al.]. Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Faslpr Mice. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213393
American Medical Association (AMA)
Lee, Hong Kyung& Kim, Ki Hun& Kim, Hyung Sook& Kim, Ji Sung& Lee, Jae Hee& Ji, Ayoung…[et al.]. Effect of a Combination of Prednisone or Mycophenolate Mofetil and Mesenchymal Stem Cells on Lupus Symptoms in MRL.Faslpr Mice. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213393
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213393