Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells
Joint Authors
Gener, Petra
Seras-Franzoso, Joaquin
Callejo, Patricia González
Andrade, Fernanda
Rafael, Diana
Martínez, Francesc
Montero, Sara
Arango, Diego
Sayós, Joan
Abasolo, Ibane
Schwartz, Simó
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-10
Country of Publication
Egypt
No. of Pages
12
Abstract EN
There are remarkable similarities in the description of cancer stem cells (CSCs) and cancer cells with mesenchymal phenotype.
Both cell types are highly tumorigenic, resistant against common anticancer treatment, and thought to cause metastatic growth.
Moreover, cancer cells are able to switch between CSC and non-CSC phenotypes and vice versa, to ensure the necessary balance within the tumor.
Likewise, cancer cells can switch between epithelial and mesenchymal phenotypes via well-described transition (EMT/MET) that is thought to be crucial for tumor propagation.
In this review, we discuss whether, and to which extend, the CSCs and mesenchymal cancer cells are overlapping phenomena in terms of mechanisms, origin, and implication for cancer treatment.
As well, we describe the dynamism of both phenotypes and involvement of the tumor microenvironment in CSC reversion and in EMT.
American Psychological Association (APA)
Gener, Petra& Seras-Franzoso, Joaquin& Callejo, Patricia González& Andrade, Fernanda& Rafael, Diana& Martínez, Francesc…[et al.]. 2018. Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213402
Modern Language Association (MLA)
Gener, Petra…[et al.]. Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213402
American Medical Association (AMA)
Gener, Petra& Seras-Franzoso, Joaquin& Callejo, Patricia González& Andrade, Fernanda& Rafael, Diana& Martínez, Francesc…[et al.]. Dynamism, Sensitivity, and Consequences of Mesenchymal and Stem-Like Phenotype of Cancer Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213402