Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects
Joint Authors
Chen, Long
Li, Lang
Xing, Fei
Peng, Jing
Peng, Kun
Wang, Yuanzheng
Xiang, Zhou
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-17
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Stem cell therapy is considered an optimistic approach to replace current treatments for cartilage defects.
Recently, human urine-derived stem cells (hUSCs), which are isolated from the urine, are studied as a promising candidate for many tissue engineering therapies due to their multipotency and sufficient proliferation activities.
However, it has not yet been reported whether hUSCs can be employed in cartilage defects.
In this study, we revealed that induced hUSCs expressed chondrogenic-related proteins, including aggrecan and collagen II, and their gene expression levels were upregulated in vitro.
Moreover, we combined hUSCs with hyaluronic acid (HA) and injected hUSCs-HA into a rabbit knee joint with cartilage defect.
Twelve weeks after the injection, the histologic analyses (HE, toluidine blue, and Masson trichrome staining), immunohistochemistry (aggrecan and collagen II), and histologic grade of the sample indicated that hUSCs-HA could stimulate much more neocartilage formation compared with hUSCs alone, pure HA, and saline, which only induced the modest cartilage regeneration.
In this study, we demonstrated that hUSCs could be a potential cell source for stem cell therapies to treat cartilage-related defects in the future.
American Psychological Association (APA)
Chen, Long& Li, Lang& Xing, Fei& Peng, Jing& Peng, Kun& Wang, Yuanzheng…[et al.]. 2018. Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects. Stem Cells International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213410
Modern Language Association (MLA)
Chen, Long…[et al.]. Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects. Stem Cells International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1213410
American Medical Association (AMA)
Chen, Long& Li, Lang& Xing, Fei& Peng, Jing& Peng, Kun& Wang, Yuanzheng…[et al.]. Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213410
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213410